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Journal of Biomedical Optics

Simulation of reflected light intensity changes during navigation and radio-frequency lesioning in the brain
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Paper Abstract

An electrode with adjacent optical fibers for measurements during navigation and radio frequency lesioning in the brain is modeled for Monte Carlo simulations of light transport in brain tissue. Relative reflected light intensity at 780 nm, I780, from this electrode and probes with identical fiber configuration are simulated using the intensity from native white matter as reference. Models are made of homogeneous native and coagulated gray, thalamus, and white matter as well as blood. Dual layer models, including models with a layer of cerebrospinal fluid between the fibers and the brain tissue, are also made. Simulated I780 was 0.16 for gray matter, 0.67 for coagulate gray matter, 0.36 for thalamus, 0.39 for coagulated thalamus, unity for white matter, 0.70 for coagulated white matter, and 0.24 for blood. Thalamic matter is also found to reflect more light than gray matter and less than white matter in clinical studies. In conclusion, the reflected light intensity can be used to differentiate between gray and white matter during navigation. Furthermore, coagulation of light gray tissue, such as the thalamus, might be difficult to detect using I780, but coagulation in darker gray tissue should result in a rapid increase of I780.

Paper Details

Date Published: 1 July 2009
PDF: 7 pages
J. Biomed. Opt. 14(4) 044040 doi: 10.1117/1.3210781
Published in: Journal of Biomedical Optics Volume 14, Issue 4
Show Author Affiliations
Johannes D. Johansson, Linköping Univ. (Sweden)
Ingemar Fredriksson, Linköping Univ. (Sweden)
Karin Wårdell, Linköping Univ. (Sweden)
Ola Eriksson, Linköping Univ. (Sweden)

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