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Journal of Biomedical Optics

Detection and monitoring of early airway injury effects of half-mustard (2-chloroethylethylsulfide) exposure using high-resolution optical coherence tomography
Author(s): Kelly A. Kreuter; Sari B. Mahon; David Sho Mukai; Jianping Su; Woonggyu Jung; Navneet Narula; S. Guo; Nicole M. Wakida; Christopher B. Raub; Michael W. Berns; Steven C. George; Zhongping Chen; Matthew Brenner
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Paper Abstract

Optical coherence tomography (OCT) is a noninvasive, high-resolution imaging technology capable of delivering real-time, near-histologic images of tissues. Mustard gas is a vesicant-blistering agent that can cause severe and lethal damage to airway and lungs. The ability to detect and assess airway injury in the clinical setting of mustard exposure is currently limited. The purpose of this study is to assess the ability to detect and monitor progression of half-mustard [2-chloroethylethylsulfide (CEES)] airway injuries with OCT techniques. A ventilated rabbit mustard exposure airway injury model is developed. A flexible fiber optic OCT probe is introduced into the distal trachea to image airway epithelium and mucosa in vivo. Progression of airway injury is observed over eight hours with OCT using a prototype time-domain superluminescent diode OCT system. OCT tracheal images from CEES exposed animals are compared to control rabbits for airway mucosal thickening and other changes. OCT detects the early occurrence and progression of dramatic changes in the experimental group after exposure to CEES. Histology and immunofluorescence staining confirms this finding. OCT has the potential to be a high resolution imaging modality capable of detecting, assessing, and monitoring treatment for airway injury following mustard vesicant agent exposures.

Paper Details

Date Published: 1 July 2009
PDF: 7 pages
J. Biomed. Opt. 14(4) 044037 doi: 10.1117/1.3210775
Published in: Journal of Biomedical Optics Volume 14, Issue 4
Show Author Affiliations
Kelly A. Kreuter, Beckman Laser Institute and Medical Ctr. (United States)
Sari B. Mahon, Beckman Laser Institute and Medical Ctr. (United States)
David Sho Mukai, Beckman Laser Institute and Medical Ctr. (United States)
Jianping Su, Beckman Laser Institute and Medical Ctr. (United States)
Woonggyu Jung, Beckman Laser Institute and Medical Ctr. (United States)
Navneet Narula, Univ. of California, Irvine (United States)
S. Guo, Beckman Laser Institute and Medical Ctr. (United States)
Nicole M. Wakida, Beckman Laser Institute and Medical Ctr. (United States)
Christopher B. Raub, Univ. of California, Irvine (United States)
Michael W. Berns, Beckman Laser Institute and Medical Ctr. (United States)
Steven C. George, Univ. of California, Irvine (United States)
Zhongping Chen, Beckman Laser Institute and Medical Ctr. (United States)
Matthew Brenner, Univ. of California, Irvine (United States)


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