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Journal of Biomedical Optics • Open Access

Potential of optical microangiography to monitor cerebral blood perfusion and vascular plasticity following traumatic brain injury in mice in vivo
Author(s): Yali Jia; Nabil J. Alkayed; Ruikang K. Wang

Paper Abstract

Optical microanglography (OMAG) is a recently developed imaging modality capable of volumetric imaging of dynamic blood perfusion, down to capillary level resolution, with an imaging depth up to 2.00 mm beneath the tissue surface. We report the use of OMAG to monitor the cerebral blood flow (CBF) over the cortex of mouse brain upon traumatic brain injury (TBI), with the cranium left intact, for a period of two weeks on the same animal. We show the ability of OMAG to repeatedly image 3-D cerebral vasculatures during pre- and post-traumatic phases, and to visualize the changes of regulated CBF and the vascular plasticity after TBI. The results indicate the potential of OMAG to explore the mechanism involved in the rehabilitation of TBI.

Paper Details

Date Published: 1 July 2009
PDF: 3 pages
J. Biomed. Opt. 14(4) 040505 doi: 10.1117/1.3207121
Published in: Journal of Biomedical Optics Volume 14, Issue 4
Show Author Affiliations
Yali Jia, Oregon Health & Science Univ. (United States)
Nabil J. Alkayed, Oregon Health & Science Univ. (United States)
Ruikang K. Wang, Oregon Health & Science Univ. (United States)

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