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Journal of Biomedical Optics

Quantitative detection of chemical compounds in human hair with coherent anti-Stokes Raman scattering microscopy
Author(s): Maxwell Zimmerley; Chia-Yu Lin; David C. Oertel; Jennifer M. Marsh; Jimmie L. Ward; Eric Olaf Potma
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Paper Abstract

Coherent anti-Stokes Raman scattering (CARS) microscopy is used to determine the distribution and concentration of selected compounds in intact human hair. By generating images based on ratiometric CARS contrast, quantitative concentration maps of both water and externally applied d-glycine are produced in the cortex of human hair fibers. Both water and d-glycine are found to homogeneously distribute throughout the cortical regions of the hair. The ability to selectively detect molecular agents in hair fibers is of direct relevance to understanding the chemical and physical mechanisms that underlie the performance of hair-care products.

Paper Details

Date Published: 1 July 2009
PDF: 7 pages
J. Biomed. Opt. 14(4) 044019 doi: 10.1117/1.3184444
Published in: Journal of Biomedical Optics Volume 14, Issue 4
Show Author Affiliations
Maxwell Zimmerley, Univ. of California, Irvine (United States)
Chia-Yu Lin, Univ. of California, Irvine (United States)
David C. Oertel, Procter & Gamble Co. (United States)
Jennifer M. Marsh, Proctor & Gamble Co. (United States)
Jimmie L. Ward, Proctor & Gamble Co. (United States)
Eric Olaf Potma, Univ. of California, Irvine (United States)


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