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Journal of Biomedical Optics

Infrared-based third and second harmonic generation imaging of cornea
Author(s): Szu-Yu Chen; Han-Chieh Yu; I-Jong Wang; Chi-Kuang Sun
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Paper Abstract

The cornea functions as an optical lens and plays an important role in vision. For corneal diagnosis and treatment such as refractive surgery, a microscopic imaging system with a 3-D cellular resolution and retinal safety is strongly desired. Recently, confocal and multiphoton microscopies have been applied to corneal imaging with visible to near-infrared light sources. To increase retinal safety, an infrared light source is be needed. In this work, an infrared-based third and second harmonic generation microscopic study of mouse eyes is reported with ~700-μm penetrability and high cellular resolution. This study provides a critical reference for future development of infrared-based corneal imaging.

Paper Details

Date Published: 1 July 2009
PDF: 7 pages
J. Biomed. Opt. 14(4) 044012 doi: 10.1117/1.3183805
Published in: Journal of Biomedical Optics Volume 14, Issue 4
Show Author Affiliations
Szu-Yu Chen, National Taiwan Univ. (Taiwan)
Han-Chieh Yu, National Taiwan Univ. Hospital (Taiwan)
I-Jong Wang, National Taiwan Univ. Hospital (Taiwan)
Chi-Kuang Sun, National Taiwan Univ. (Taiwan)

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