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Journal of Biomedical Optics

Polarization-sensitive optical coherence tomography for the nondestructive assessment of the remineralization of dentin
Author(s): Saman K. Manesh; Cynthia L. Darling; Daniel Fried
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Paper Abstract

Previous studies have demonstrated that polarization-sensitive optical coherence tomography (PS-OCT) can be used to image caries lesions in dentin, measure nondestructively the severity of dentin demineralization, and determine the efficacy of intervention with anticaries agents including fluoride and lasers. The objective of this study is to determine if PS-OCT can be used to nondestructively measure a reduction in the reflectivity of dentin lesions after exposure to a remineralization solution. Although studies have shown the ability of PS-OCT to image the remineralization of lesions in enamel, none have included dentin. PS-OCT images of dentin surfaces are acquired after exposure to an artificial demineralizing solution for six days and a remineralizing solution for 20 days. The integrated reflectivity, depth of demineralization, and thickness of the layer of remineralization are calculated for each of the two treatment groups on each sample. Polarized light microscopy and microradiography are used to measure lesion severity on histological thin sections for comparison. PS-OCT successfully measured the formation of a layer of increased mineral content near the lesion surface. Polorized light microscopy (PLM) and transverse microradiography (TMR) corroborated those results. PS-OCT can be used for the nondestructive measurement of the remineralization of dentin.

Paper Details

Date Published: 1 July 2009
PDF: 6 pages
J. Biomed. Opt. 14(4) 044002 doi: 10.1117/1.3158995
Published in: Journal of Biomedical Optics Volume 14, Issue 4
Show Author Affiliations
Saman K. Manesh, Univ. of California, San Francisco (United States)
Cynthia L. Darling, Univ. of California, San Francisco (United States)
Daniel Fried, Univ. of California, San Francisco (United States)

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