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Journal of Biomedical Optics

Multimodality bonchoscopic imaging of tracheopathica osteochondroplastica
Author(s): Henri G. Colt; Septimiu Dan Murgu; Yeh-Chan Ahn; Matthew Brenner
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Paper Abstract

Results of a commercial optical coherence tomography system used as part of a multimodality diagnostic bronchoscopy platform are presented for a 61-year-old patient with central airway obstruction from tracheopathica osteochondroplastica. Comparison to results of white-light bronchoscopy, histology, and endobronchial ultrasound examination are accompanied by a discussion of resolution, penetration depth, contrast, and field of view of these imaging modalities. White-light bronchoscopy revealed irregularly shaped, firm submucosal nodules along cartilaginous structures of the anterior and lateral walls of the trachea, sparing the muscular posterior membrane. Endobronchial ultrasound showed a hyperechoic density of 0.4 cm thickness. optical coherence tomography (OCT) was performed using a commercially available, compact time-domain OCT system (Niris System, Imalux Corp., Cleveland, Ohio) with a magnetically actuating probe (two-dimensional, front imaging, and inside actuation). Images showed epithelium, upper submucosa, and osseous submucosal nodule layers corresponding with histopathology. To our knowledge, this is the first time these commercially available systems are used as part of a multimodality bronchoscopy platform to study diagnostic imaging of a benign disease causing central airway obstruction. Further studies are needed to optimize these systems for pulmonary applications and to determine how new-generation imaging modalities will be integrated into a multimodality bronchoscopy platform.

Paper Details

Date Published: 1 May 2009
PDF: 5 pages
J. Biomed. Opt. 14(3) 034035 doi: 10.1117/1.3155524
Published in: Journal of Biomedical Optics Volume 14, Issue 3
Show Author Affiliations
Henri G. Colt, Univ. of California, Irvine (United States)
Septimiu Dan Murgu, Univ. of California, Irvine (United States)
Yeh-Chan Ahn, Univ. of California, Irvine (United States)
Matthew Brenner, Univ. of California, Irvine (United States)


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