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Journal of Biomedical Optics

Early diagnosis of melanotic melanoma based on laser-induced melanin fluorescence
Author(s): Reinhold Eichhorn; Gerd Wessler; Matthias Scholz; Dieter Leupold; Goran Stankovic; Susanne Buder; Markus Stuecker; Klaus Hoffmann
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Paper Abstract

Because of the increasing incidence of skin cancer, interest in using the autofluorescence of skin tissue as a noninvasive tool for early diagnosis is enforced. Focus is especially on malignant melanotic melanoma. On the basis of a newly developed method to selectively excite melanin fluorescence of skin tissue by stepwise two-photon excitation with nanosecond laser pulses at 810 nm, we have investigated information from this melanin fluorescence with respect to the differentiation of pigmented lesions. A distinct difference in the melanin fluorescence spectrum of malignant melanoma (including melanoma in situ) when compared to that of benign melanocytic lesions (i.e., common nevi) has been found for freshly excised samples as well as for histopathological samples. There is also specific fluorescence from dysplastic nevi. In this way, early detection of malignant melanoma is possible.

Paper Details

Date Published: 1 May 2009
PDF: 7 pages
J. Biomed. Opt. 14(3) 034033 doi: 10.1117/1.3155511
Published in: Journal of Biomedical Optics Volume 14, Issue 3
Show Author Affiliations
Reinhold Eichhorn
Gerd Wessler
Matthias Scholz, LTB Lasertechnik Berlin GmbH (Germany)
Dieter Leupold, LTB Lasertechnik Berlin GmbH (Germany)
Goran Stankovic, LTB Lasertechnik Berlin GmbH (Germany)
Susanne Buder, Vivantes Klinikum Neukölin (Germany)
Markus Stuecker, Ruhr-Univ. Bochum (Germany)
Klaus Hoffmann, Ruhr-Univ. Bochum (Germany)

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