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Journal of Biomedical Optics

Use of an oxygen-carrying blood substitute to improve intravascular optical coherence tomography imaging
Author(s): Khiet C. Hoang; Ahamd Edris; Jianping Su; David Sho Mukai; Sari B. Mahon; Artiom D. Petrov; Morton Kern; Chowdhury Ahsan; Zhongping Chen; Bruce Jason Tromberg; Jagat Narula; Matthew Brenner
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Paper Abstract

Optical coherence tomography (OCT) is a catheter-based imaging technology with powerful resolution capable of identifying vulnerable plaques and guiding coronary intervention. However, a significant limitation of intravascular OCT imaging is its attenuation by blood. We propose that the use of an oxygen-carrying blood substitute could potentially optimize OCT image quality. Surgical isolation of the descending thoracic aorta of six rabbits is performed, followed by intravascular OCT imaging of the abdominal aorta. Perfluorodecalin (PFD) is oxygenated using a bubble-through technique with 100% oxygen. OCT imaging is performed and compared using three different flushing modalities: PFD; saline; and blood. OCT imaging of the rabbit abdominal aorta is successful in all of the subjects. In each of the six studied subjects, flushing with PFD consistently provides dramatically better imaging of the vessel wall tissue structures. OCT image quality is highly dependent on the ability of the flushing modality to remove blood from the imaging field. From this proof-of-concept study, we demonstrate that endovascular flushing with an oxygen-carrying blood substitute (PFD) is optically superior to saline flushing for intravascular imaging.

Paper Details

Date Published: 1 May 2009
PDF: 4 pages
J. Biomed. Opt. 14(3) 034028 doi: 10.1117/1.3153895
Published in: Journal of Biomedical Optics Volume 14, Issue 3
Show Author Affiliations
Khiet C. Hoang, Univ. of California, Irvine (United States)
Ahamd Edris, Univ. of California, Irvine (United States)
Jianping Su, Beckman Laser Institute and Medical Ctr. (United States)
David Sho Mukai, Beckman Laser Institute and Medical Ctr. (United States)
Sari B. Mahon, Beckman Laser Institute and Medical Ctr. (United States)
Artiom D. Petrov, Univ. of California, Irvine (United States)
Morton Kern, Univ. of California, Irvine (United States)
Chowdhury Ahsan, Nevada Heart & Vascular Ctr. (United States)
Zhongping Chen, Univ. of California, Irvine (United States)
Bruce Jason Tromberg, Beckman Laser Institute and Medical Ctr. (United States)
Jagat Narula, Univ. of California, Irvine (United States)
Matthew Brenner, Univ. of California, Irvine (United States)


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