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Journal of Biomedical Optics

Glucose concentration monitoring using a small Fabry-Pérot etalon
Author(s): Joerg Martini; Peter Kiesel; Jeffrey N. Roe; Richard H. Bruce
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Paper Abstract

Accurate measurements of aqueous glucose concentrations have been made in a double-chamber Fabry-Pérot etalon that can be miniaturized for subcutaneous implantation to determine the concentration of glucose in interstitial fluid. In general, optical approaches to glucose detection measure light intensity, which in tissue varies due to inherent scattering and absorption. In our measurements, we compare the spectral positions of transmission maximums in two adjunct sections of an etalon in order to determine the refractive index difference between these sections and therefore we can tolerate large changes in intensity. With this approach, we were able to determine aqueous glucose concentrations between 0 mg/dl and 700 mg/dl within the precision of our reference measurement (±2.5 mg/dl or 2% of the measurement value). The use of reference cavities eliminates interference due to temperature variations, and we show the temperature independence over a temperature range of 32°C to 42°C. Furthermore, external filters eliminate interference from large molecule contaminants.

Paper Details

Date Published: 1 May 2009
PDF: 8 pages
J. Biomed. Opt. 14(3) 034029 doi: 10.1117/1.3153848
Published in: Journal of Biomedical Optics Volume 14, Issue 3
Show Author Affiliations
Joerg Martini, Palo Alto Research Center, Inc. (United States)
Peter Kiesel, Palo Alto Research Center, Inc. (United States)
Jeffrey N. Roe, Palo Alto Research Center, Inc. (United States)
Richard H. Bruce, Palo Alto Research Center, Inc. (United States)

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