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Journal of Biomedical Optics • Open Access

In-vivo imaging of murine tumors using complete-angle projection fluorescence molecular tomography
Author(s): Nikolaos C. Deliolanis; Joshua Dunham; Thomas Wurdinger; Jose-Luiz Figueiredo; Tannous Bakhos; Vasilis Ntziachristos

Paper Abstract

We interrogate the ability of free-space fluorescence tomography to image small animals in vivo using charge-coupled device (CCD) camera measurements over 360-deg noncontact projections. We demonstrate the performance of normalized dual-wavelength measurements that are essential for in-vivo use, as they account for the heterogeneous distribution of photons in tissue. In-vivo imaging is then showcased on mouse lung and brain tumors cross-validated by x-ray microcomputed tomography and histology.

Paper Details

Date Published: 1 May 2009
PDF: 3 pages
J. Biomed. Opt. 14(3) 030509 doi: 10.1117/1.3149854
Published in: Journal of Biomedical Optics Volume 14, Issue 3
Show Author Affiliations
Nikolaos C. Deliolanis, Helmholtz Zentrum München, GmbH (Germany)
Joshua Dunham, Massachusetts General Hospital (United States)
Thomas Wurdinger, Massachusetts General Hospital (United States)
Jose-Luiz Figueiredo, Massachusetts General Hospital (United States)
Tannous Bakhos, Massachusetts General Hospital (United States)
Vasilis Ntziachristos, Massachusetts General Hospital (United States)

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