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Journal of Biomedical Optics • Open Access

Intraluminal fluorescence spectroscopy catheter with ultrasound guidance

Paper Abstract

We demonstrate the feasibility of a time-resolved fluorescence spectroscopy (TRFS) technique for intraluminal investigation of arterial vessel composition under intravascular ultrasound (IVUS) guidance. A prototype 1.8-mm (5.4 Fr) catheter combining a side-viewing optical fiber (SVOF) and an IVUS catheter was constructed and tested with in vitro vessel phantoms. The prototype catheter can locate a fluorophore in the phantom vessel wall, steer the SVOF in place, perform blood flushing under flow conditions, and acquire high-quality TRFS data using 337-nm wavelength excitation. The catheter steering capability used for the coregistration of the IVUS image plane and the SVOF beam produce a guiding precision to an arterial phantom wall site location of 0.53±0.16 mm. This new intravascular multimodal catheter enables the potential for in vivo arterial plaque composition identification using TRFS.

Paper Details

Date Published: 1 May 2009
PDF: 3 pages
J. Biomed. Opt. 14(3) 030505 doi: 10.1117/1.3146813
Published in: Journal of Biomedical Optics Volume 14, Issue 3
Show Author Affiliations
Douglas N. Stephens, Univ. of California, Davis (United States)
Jesung Park, Univ. of California, Davis (United States)
Yang Sun, Univ. of California, Davis (United States)
Thanassis Papaioannou, Cedars-Sinai Medical Ctr. (United States)
Laura Marcu, Univ. of California, Davis (United States)

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