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Journal of Biomedical Optics

Enhanced detection of early-stage oral cancer in vivo by optical coherence tomography using multimodal delivery of gold nanoparticles
Author(s): Chang Soo Kim; Petra B. B. Wilder-Smith; Yeh-Chan Ahn; Lih-Huei L. Liaw; Zhongping Chen; Young Jik Kwon
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Paper Abstract

Contrast in optical coherence tomography (OCT) images can be enhanced by utilizing surface plasmon resonant gold nanoparticles. To improve the poor in vivo transport of gold nanoparticles through biological barriers, an efficient delivery strategy is needed. In this study, the improved penetration and distribution of gold nanoparticles were achieved by microneedle and ultrasound, respectively, and it was demonstrated that this multimodal delivery of antibody-conjugated PEGylated gold nanoparticles enhanced the contrast in in vivo OCT images of oral dysplasia in a hamster model.

Paper Details

Date Published: 1 May 2009
PDF: 8 pages
J. Biomed. Opt. 14(3) 034008 doi: 10.1117/1.3130323
Published in: Journal of Biomedical Optics Volume 14, Issue 3
Show Author Affiliations
Chang Soo Kim, Univ. of California, Irvine (United States)
Petra B. B. Wilder-Smith, Univ. of California, Irvine (United States)
Yeh-Chan Ahn, Univ. of California, Irvine (United States)
Lih-Huei L. Liaw, Univ. of California, Irvine (United States)
Zhongping Chen, Univ. of California, Irvine (United States)
Young Jik Kwon, Univ. of California, Irvine (United States)

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