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Journal of Biomedical Optics • Open Access

Design and implementation of fiber-based multiphoton endoscopy with microelectromechanical systems scanning
Author(s): Shuo Tang; Woonggyu Jung; Daniel T. McCormick; Tuqiang Xie; Jianping Su; Yeh-Chan Ahn; Bruce Jason Tromberg; Zhongping Chen

Paper Abstract

A multiphoton endoscopy system has been developed using a two-axis microelectromechanical systems (MEMS) mirror and double-cladding photonic crystal fiber (DCPCF). The MEMS mirror has a 2-mm-diam, 20-deg optical scanning angle, and 1.26-kHz and 780-Hz resonance frequencies on the x and y axes. The maximum number of resolvable focal spots of the MEMS scanner is 720×720 on the x and y axes, which indicates that the MEMS scanner can potentially support high-resolution multiphoton imaging. The DCPCF is compared with standard single-mode fiber and hollow-core photonic bandgap fiber on the basis of dispersion, attenuation, and coupling efficiency properties. The DCPCF has high collection efficiency, and its dispersion can be compensated by grating pairs. Three configurations of probe design are investigated, and their imaging quality and field of view are compared. A two-lens configuration with a collimation and a focusing lens provides the optimum imaging performance and packaging flexibility. The endoscope is applied to image fluorescent microspheres and bovine knee joint cartilage.

Paper Details

Date Published: 1 May 2009
PDF: 7 pages
J. Biomed. Opt. 14(3) 034005 doi: 10.1117/1.3127203
Published in: Journal of Biomedical Optics Volume 14, Issue 3
Show Author Affiliations
Shuo Tang, The Univ. of British Columbia (Canada)
Woonggyu Jung, Univ. of California, Irvine (United States)
Daniel T. McCormick, AdvancedMEMS (United States)
Tuqiang Xie
Jianping Su, Univ. of California, Irvine (United States)
Yeh-Chan Ahn, Univ. of California, Irvine (United States)
Bruce Jason Tromberg, Univ. of California, Irvine (United States)
Zhongping Chen, Univ. of California, Irvine (United States)

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