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Journal of Biomedical Optics • Open Access

Imaging of glioma tumor with endogenous fluorescence tomography

Paper Abstract

Tomographic imaging of a glioma tumor with endogenous fluorescence is demonstrated using a noncontact single-photon counting fan-beam acquisition system interfaced with microCT imaging. The fluorescence from protoporphyrin IX (PpIX) was found to be detectable, and allowed imaging of the tumor from within the cranium, even though the tumor presence was not visible in the microCT image. The combination of single-photon counting detection and normalized fluorescence to transmission detection at each channel allowed robust imaging of the signal. This demonstrated use of endogenous fluorescence stimulation from aminolevulinic acid (ALA) and provides the first in vivo demonstration of deep tissue tomographic imaging with protoporphyrin IX.

Paper Details

Date Published: 1 May 2009
PDF: 3 pages
J. Biomed. Opt. 14(3) 030501 doi: 10.1117/1.3127202
Published in: Journal of Biomedical Optics Volume 14, Issue 3
Show Author Affiliations
Dax S. Kepshire, Dartmouth College (United States)
Summer L. Gibbs-Strauss, Beth Israel Deaconess Medical Ctr. (United States)
Julia A. O'Hara, Dartmouth Medical School (United States)
Michael Hutchins, ART Advanced Research Technologies Inc. (Canada)
Niculae Mincu, ART Advanced Research Technologies Inc. (Canada)
Frederic Leblond, Dartmouth College (United States)
Mario Khayat, ART Advanced Research Technologies Inc. (Canada)
Hamid Dehghani, The Univ. of Birmingham (United Kingdom)
Subhadra Srinivasan, Dartmouth College (United States)
Brian W. Pogue, Dartmouth College (United States)

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