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Journal of Biomedical Optics

Laser-induced tissue hyperthermia mediated by gold nanoparticles: toward cancer phototherapy
Author(s): Georgy Sergeevich Terentyuk; Galina N. Maslyakova; Leyla V. Suleymanova; Nikolay Grigorievich Khlebtsov; Boris Nokolaevich Khlebtsov; Garif Gazizovich Akchurin; Irina Leonidovna Maksimova; Valery V. Tuchin
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Paper Abstract

We describe an application of plasmonic silica/gold nanoshells to produce a controllable laser hyperthermia in tissues with the aim of the enhancement of cancer photothermal therapy. Laser irradiation parameters are optimized on the basis of preliminary experimental studies using a test-tube phantom and laboratory rats. Temperature distributions on the animal skin surface at hypodermic and intramuscular injection of gold nanoparticle suspensions and affectations by the laser radiation are measured in vivo with a thermal imaging system. The results of temperature measurements are compared with tissue histology.

Paper Details

Date Published: 1 March 2009
PDF: 9 pages
J. Biomed. Opt. 14(2) 021016 doi: 10.1117/1.3122371
Published in: Journal of Biomedical Optics Volume 14, Issue 2
Show Author Affiliations
Georgy Sergeevich Terentyuk, Saratov State Univ. (Russian Federation)
Galina N. Maslyakova, Saratov State Medical Univ. (Russian Federation)
Leyla V. Suleymanova, Saratov State Medical Univ. (Russian Federation)
Nikolay Grigorievich Khlebtsov, Institute of Biochemistry and Physiology of Plants and Microorganisms (Russian Federation)
Boris Nokolaevich Khlebtsov, Institute of Biochemistry and Physiology of Plants and Microorganisms (Russian Federation)
Garif Gazizovich Akchurin, Saratov State Univ. (Russian Federation)
Irina Leonidovna Maksimova, Saratov State Univ. (Russian Federation)
Valery V. Tuchin, Saratov State Univ. (Russian Federation)

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