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Journal of Biomedical Optics

Bipolar cellular morphology of malignant melanoma in unstained human melanoma skin tissue
Author(s): Kai Zhang; Wenkai Zhang; Chia-Yi Yang; Haw Yang
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Paper Abstract

Microstructures of unstained human melanoma skin tissues have been examined by multimodal nonlinear optical microscopy. The polarized shape of the individual melanoma cell can be readily recognized-a phenotype that has been identified in laboratory cultures as characteristic of proliferating melanocytes but has not been demonstrated in clinical instances. The results thus provide snapshots of invading melanoma cells in their native environment and suggest a practical means of connecting in vitro laboratory studies to in vivo processes.

Paper Details

Date Published: 1 March 2009
PDF: 9 pages
J. Biomed. Opt. 14(2) 024042 doi: 10.1117/1.3120491
Published in: Journal of Biomedical Optics Volume 14, Issue 2
Show Author Affiliations
Kai Zhang, Univ. of California, Berkeley (United States)
Wenkai Zhang, Univ. of California, Berkeley (United States)
Chia-Yi Yang, Taipei City Hospital (Taiwan)
Haw Yang, Univ. of California, Berkeley (United States)


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