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Journal of Biomedical Optics

Nanophotothermolysis of multiple scattered cancer cells with carbon nanotubes guided by time-resolved infrared thermal imaging
Author(s): Alexandru S. Biris; Dorin Boldor; Jason Palmer; William Todd Monroe; Meena Mahmood; Enkeleda Dervishi; Yang Xu; Zhongrui Li; Ekaterina I. Galanzha; Vladimir P. Zharov
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Paper Abstract

Nanophotothermolysis with long laser pulses for treatment of scattered cancer cells and their clusters is introduced with the main focus on real-time monitoring of temperature dynamics inside and around individual cancer cells labeled with carbon nanotubes. This technique utilizes advanced time- and spatially-resolved thermal radiometry imaging for the visualization of laser-induced temperature distribution in multiple-point absorbing targets. The capability of this approach was demonstrated for monitoring of thermal effects under long laser exposure (from millisecond to seconds, wavelength 1064 nm, maximum power 1 W) of cervical cancer HeLa cells labeled with carbon nanotubes in vitro. The applications are discussed with a focus on the nanophotothermolysis of small tumors, tumor margins, or micrometastases under the guidance of near-IR and microwave radiometry.

Paper Details

Date Published: 1 March 2009
PDF: 6 pages
J. Biomed. Opt. 14(2) 021007 doi: 10.1117/1.3119135
Published in: Journal of Biomedical Optics Volume 14, Issue 2
Show Author Affiliations
Alexandru S. Biris, Univ. of Arkansas at Little Rock (United States)
Dorin Boldor, Louisiana State Univ. (United States)
Jason Palmer, Louisiana State Univ. (United States)
William Todd Monroe, Louisiana State Univ. (United States)
Meena Mahmood, Univ. of Arkansas at Little Rock (United States)
Enkeleda Dervishi, Univ. of Arkansas at Little Rock (United States)
Yang Xu, Univ. of Arkansas at Little Rock (United States)
Zhongrui Li, Univ. of Arkansas at Little Rock (United States)
Ekaterina I. Galanzha, Univ. of Arkansas for Medical Sciences (United States)
Vladimir P. Zharov, Univ. of Arkansas for Medical Sciences (United States)


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