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Journal of Biomedical Optics

Three-dimensional pointwise comparison of human retinal optical property at 845 and 1060 nm using optical frequency domain imaging
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Paper Abstract

To compare the optical properties of the human retina, 3-D volumetric images of the same eye are acquired with two nearly identical optical coherence tomography (OCT) systems at center wavelengths of 845 and 1060 nm using optical frequency domain imaging (OFDI). To characterize the contrast of individual tissue layers in the retina at these two wavelengths, the 3-D volumetric data sets are carefully spatially matched. The relative scattering intensities from different layers such as the nerve fiber, photoreceptor, pigment epithelium, and choroid are measured and a quantitative comparison is presented. OCT retinal imaging at 1060 nm is found to have a significantly better depth penetration but a reduced contrast between the retinal nerve fiber, the ganglion cell, and the inner plexiform layers compared to the OCT retinal imaging at 845 nm.

Paper Details

Date Published: 1 March 2009
PDF: 5 pages
J. Biomed. Opt. 14(2) 024016 doi: 10.1117/1.3119103
Published in: Journal of Biomedical Optics Volume 14, Issue 2
Show Author Affiliations
Yueli Chen, Massachusetts Institute of Technology (United States)
Daina L. Burnes, Massachusetts General Hospital (United States)
Martijn D. de Bruin, Univ. van Amsterdam (Netherlands)
Mircea Mujat, Physical Sciences Inc. (United States)
Johannes F. de Boer, Vrije Univ. Amsterdam (Netherlands)


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