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Journal of Biomedical Optics • Open Access

Application of hyperosmotic agent to determine gastric cancer with optical coherence tomography ex vivo in mice
Author(s): Honglian Xiong; Zhouyi Guo; Chang-Chun Zeng; Like Wang; Yonghong He; Song-Hao Liu

Paper Abstract

Noninvasive tumor imaging could lead to the early detection and timely treatment of cancer. Optical coherence tomography (OCT) has been reported as an ideal diagnostic tool for distinguishing tumor tissues from normal tissues based on structural imaging. In this study, the capability of OCT for functional imaging of normal and tumor tissues based on time- and depth-resolved quantification of the permeability of biomolecules through these tissues is investigated. The orthotopic graft model of gastric cancer in nude mice is used, normal and tumor tissues from the gastric wall are imaged, and a diffusion of 20% aqueous solution of glucose in normal stomach tissues and gastric tumor tissues is monitored and quantified as a function of time and tissue depth by an OCT system. Our results show that the permeability coefficient is (0.94±0.04)×10-5 cm/s in stomach tissues and (5.32±0.17)×10-5 cm/s in tumor tissues, respectively, and that tumor tissues have a higher permeability coefficient compared to normal tissues in optical coherence tomographic images. From the results, it is found that the accurate and sensitive assessment of the permeability coefficients of normal and tumor tissues offers an effective OCT image method for detection of tumor tissues and clinical diagnosis.

Paper Details

Date Published: 1 March 2009
PDF: 5 pages
J. Biomed. Opt. 14(2) 024029 doi: 10.1117/1.3103341
Published in: Journal of Biomedical Optics Volume 14, Issue 2
Show Author Affiliations
Honglian Xiong, South China Normal Univ. (China)
Zhouyi Guo, South China Normal Univ. (China)
Chang-Chun Zeng, South China Normal Univ. (China)
Like Wang, Harbin Institute of Technology (China)
Yonghong He, Tsinghua Univ. (China)
Song-Hao Liu, South China Normal Univ. (China)

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