Share Email Print
cover

Journal of Biomedical Optics

Spatiotemporal image correlation spectroscopy measurements of flow demonstrated in microfluidic channels
Author(s): Molly J. Rossow; William W. Mantulin; Enrico Gratton
Format Member Price Non-Member Price
PDF $20.00 $25.00
cover GOOD NEWS! Your organization subscribes to the SPIE Digital Library. You may be able to download this paper for free. Check Access

Paper Abstract

Accurate blood flow measurements during surgery can improve an operation's chance of success. We developed near-infrared spatio-temporal image spectroscopy (NIR-STICS), which has the potential to make blood flow measurements that are difficult to accomplish with existing methods. Specifically, we propose the technique and we show feasibility on phantom measurements. NIR-STICS has the potential of measuring the fluid velocity in small blood vessels (less than 1 mm in diameter) and of creating a map of blood flow rates over an area of approximately 1 cm2. NIR-STICS employs near-infrared spectroscopy to probe inside blood vessel walls and spatiotemporal image correlation spectroscopy to directly-without the use of a model-extract fluid velocity from the fluctuations within an image. We present computer simulations and experiments on a phantom system that demonstrate the effectiveness of NIR-STICS.

Paper Details

Date Published: 1 March 2009
PDF: 7 pages
J. Biomed. Opt. 14(2) 024014 doi: 10.1117/1.3088203
Published in: Journal of Biomedical Optics Volume 14, Issue 2
Show Author Affiliations
Molly J. Rossow, Univ. of California, Irvine (United States)
William W. Mantulin, Univ. of California, Irvine (United States)
Enrico Gratton, Univ. of California, Irvine (United States)


© SPIE. Terms of Use
Back to Top