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Journal of Biomedical Optics

Spatiotemporal image correlation spectroscopy measurements of flow demonstrated in microfluidic channels
Author(s): Molly J. Rossow; William W. Mantulin; Enrico Gratton
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Paper Abstract

Accurate blood flow measurements during surgery can improve an operation's chance of success. We developed near-infrared spatio-temporal image spectroscopy (NIR-STICS), which has the potential to make blood flow measurements that are difficult to accomplish with existing methods. Specifically, we propose the technique and we show feasibility on phantom measurements. NIR-STICS has the potential of measuring the fluid velocity in small blood vessels (less than 1 mm in diameter) and of creating a map of blood flow rates over an area of approximately 1 cm2. NIR-STICS employs near-infrared spectroscopy to probe inside blood vessel walls and spatiotemporal image correlation spectroscopy to directly-without the use of a model-extract fluid velocity from the fluctuations within an image. We present computer simulations and experiments on a phantom system that demonstrate the effectiveness of NIR-STICS.

Paper Details

Date Published: 1 March 2009
PDF: 7 pages
J. Biomed. Opt. 14(2) 024014 doi: 10.1117/1.3088203
Published in: Journal of Biomedical Optics Volume 14, Issue 2
Show Author Affiliations
Molly J. Rossow, Univ. of California, Irvine (United States)
William W. Mantulin, Univ. of California, Irvine (United States)
Enrico Gratton, Univ. of California, Irvine (United States)


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