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Journal of Biomedical Optics

Silicon nanoparticles produced by femtosecond laser ablation in water as novel contamination-free photosensitizers
Author(s): David Rioux; Marie Laferrière; Alexandre Douplik; Duoaud Shah; Lothar D. Lilge; Andrei V. Kabashin; Michel Meunier
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Paper Abstract

We report the synthesis of novel inorganic contamination-free photosensitizers based on colloidal silicon nanoparticles prepared by laser ablation in pure deionized water. We show that such nanoparticles are capable of generating singlet oxygen (1O2) under laser irradiation with a yield estimated at 10% of that of photofrin, which makes them a potential candidate for therapeutics, antiseptics, or disinfectants. We also discuss a model of 1O2 generation and the possibility for optimizing its release. Potential advantages of such novel inorganic photosensitizers include stable and nonphotobleaching 1O2 release, easy removal, and low dark toxicity.

Paper Details

Date Published: 1 March 2009
PDF: 5 pages
J. Biomed. Opt. 14(2) 021010 doi: 10.1117/1.3086608
Published in: Journal of Biomedical Optics Volume 14, Issue 2
Show Author Affiliations
David Rioux, Ecole Polytechnique de Montréal (Canada)
Marie Laferrière, École Polytechnique de Montréal (Canada)
Alexandre Douplik, Friedrich-Alexander-Univ. Erlangen-Nürnberg (Germany)
Duoaud Shah, Univ. Health Network (Canada)
Lothar D. Lilge, Univ. Health Network (Canada)
Andrei V. Kabashin, Ecole Polytechnique de Montréal (Canada)
Michel Meunier, Ecole Polytechnique de Montréal (Canada)


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