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Journal of Biomedical Optics

Colloidal mesoporous silica nanoparticles with protoporphyrin IX encapsulated for photodynamic therapy
Author(s): Jun Qian; Arash Gharibi; Sailing He
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Paper Abstract

Protoporphyrin IX (PpIX)-encapsulated mesoporous silica nanoparticles were synthesized, characterized, and utilized for photodynamic therapy (PDT) of cancer. Silica encapsulation is relatively transparent for activated light and can protect the PpIX against denaturation induced by the extreme bioenvironment. The mesoporous silica can also ensure that the encapsulated PpIX can be well-contacted with oxygen, stimulated, and released. PpIX-encapsulated colloidal mesoporous silica nanoparticles were uptaken by tumor cells in vitro, and the effect of photon-induced toxicity was demonstrated after comparison with some control experiments. The surface of PpIX-encapsulated silica nanoparticles can be grafted with appropriate functionalized groups and conjugated with certain biomolecules for specific targeting.

Paper Details

Date Published: 1 January 2009
PDF: 6 pages
J. Biomed. Opt. 14(1) 014012 doi: 10.1117/1.3083427
Published in: Journal of Biomedical Optics Volume 14, Issue 1
Show Author Affiliations
Jun Qian, Zhejiang Univ. (China)
Arash Gharibi, Lunds Tekniska Högskola (Sweden)
Sailing He, Zhejiang Univ. (China)

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