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Journal of Biomedical Optics

Photoacoustic molecular imaging with antibody-functionalized single-walled carbon nanotubes for early diagnosis of tumor
Author(s): Liangzhong Xiang; Yi Yuan; Xing Da; Zhongmin Ou; Sihua Yang; Feifan Zhou
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Paper Abstract

Single-walled carbon nanotubes (SWNT) in a poly(ethylene)ghycol solution are a biocompatible transporters with strong optical absorption in the near-infrared region, in which the biological tissue is almost transparent with very low absorbance. Here, antibody-functionalized SWNTs for tumor early detection with photoacoustic molecular imaging in vivo are reported. To lay the groundwork for this goal and insure system stability, images were collected in tissue simulating phantoms to determine appropriate detectable concentrations of SWNTs. Preliminary in vitro and in vivo results showed that a high contrast and a high efficient targeting of integrin αvβ3 positive U87 human glioblastoma tumours in mice could be achieved. The nontoxicity of functionalized SWNTs has also been demonstrated in our experiment; this feature ensures that SWNTs can be used for clinical applications. This study suggests that photoacoustic molecular imaging with antibody-functionalized SWNTs has the potential to be an effective early tumor diagnosis method.

Paper Details

Date Published: 1 March 2009
PDF: 7 pages
J. Biomed. Opt. 14(2) 021008 doi: 10.1117/1.3078809
Published in: Journal of Biomedical Optics Volume 14, Issue 2
Show Author Affiliations
Liangzhong Xiang, South China Normal Univ. (China)
Yi Yuan, South China Normal Univ. (China)
Xing Da, South China Normal Univ. (China)
Zhongmin Ou, South China Normal Univ. (China)
Sihua Yang, South China Normal Univ. (China)
Feifan Zhou, South China Normal Univ. (China)


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