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Journal of Biomedical Optics

Cancer photothermal therapy in the near-infrared region by using single-walled carbon nanotubes
Author(s): Feifan Zhou; Xing Da; Zhongmin Ou; Baoyan Wu; Daniel E. Resasco; Wei R. Chen
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Paper Abstract

Single-walled carbon nanotubes (SWNTs) have a high optical absorbance in the near-infrared (NIR) region. In this special optical window, biological systems are known to be highly transparent. The optical properties of SWNTs provide an opportunity for selective photothermal therapy for cancer treatment. Specifically, CoMoCAT® nanotubes with a uniform size (about 0.81 nm) and a narrow absorption peak at 980 nm are ideal candidates for such a novel approach. Here, CoMoCAT® SWNTs are conjugated to folate, which can bind specifically to the surface of the folate receptor tumor markers. Folate-SWNT (FA-SWNT) targeted tumor cells were irradiated by a 980-nm laser. In our in vitro and in vivo experiments, FA-SWNT effectively enhanced the photothermal destruction on tumor cells and noticeably spared the photothermal destruction for nontargeted normal cells. Thus, SWNTs, combined with suitable tumor markers, can be used as novel nanomaterials for selective photothermal therapy for cancer treatment.

Paper Details

Date Published: 1 March 2009
PDF: 7 pages
J. Biomed. Opt. 14(2) 021009 doi: 10.1117/1.3078803
Published in: Journal of Biomedical Optics Volume 14, Issue 2
Show Author Affiliations
Feifan Zhou, South China Normal Univ. (China)
Xing Da, South China Normal Univ. (China)
Zhongmin Ou, South China Normal Univ. (China)
Baoyan Wu, South China Normal Univ. (China)
Daniel E. Resasco, Univ. of Oklahoma (United States)
Wei R. Chen, Univ. of Central Oklahoma (United States)

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