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Journal of Biomedical Optics

Combination of different noninvasive measuring techniques: a new approach to increase accuracy of peripheral near infrared spectroscopy
Author(s): Gerhard Pichler; Karin Grossauer; Elisabeth Peichl; Andrea Gaster; Andrea Berghold; Gerold Schwantzer; Heinz Zotter; William Müller; Berndt Urlesberger
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Paper Abstract

One of the problems of near-infrared-spectroscopy (NIRS) measurements is low reproducibility. The aim of the present study was to introduce quality criteria to increase reproducibility of peripheral NIRS measurements. In a prospective cohort study in 40 neonates, repeated NIRS measurements were performed on the calf. During five "reapplication" periods (of NIRS optodes), five "measurements" (venous occlusions) were performed. Tissue oxygenation index (TOI), mixed venous oxygenation (SvO2), fractional oxygen extraction (FOE), hemoglobin flow (Hbflow), oxygen delivery (DO2), and oxygen consumption (VO2) were assessed. Measurements with linear changes during venous occlusions were included for further analysis (first quality criterion: R2>0.95). The second quality criterion was the equation 0 ≤ TOI-SvO2 ≤(SaO2-SvO2)×0.2. Variance components and mean standard deviations were analyzed after introduction of the quality criteria. Variance components of reapplication and measurement decreased after introduction of the second quality criterion (TOI: 46.6–35.0%, SvO2: 76.8–38.2%, FOE: 73.1–37.5%, Hbflow: 70.3–51.9%, DO2: 71.5–52.7%, and VO2: 70.9–63.8%). Mean standard deviations of TOI (6.6±3.0 to 4.7±3.2%), SvO2 (11.1±4.8 to 5.7±3.9%), FOE (11.3±4.8 to 5.9±4.0%), Hbflow (4.3±2.0 to 2.9±1.6 μmol/100 mL/min), and DO2 (17.8±7.6 to 11.4±6.2 μmol/100 mL/min) decreased significantly, too. Only 12% of measurements fulfilled both quality criteria. With the introduction of two quality criteria, test–retest variability of peripheral NIRS measurements decreased significantly and reproducibility increased significantly.

Paper Details

Date Published: 1 January 2009
PDF: 6 pages
J. Biomed. Opt. 14(1) 014014 doi: 10.1117/1.3076193
Published in: Journal of Biomedical Optics Volume 14, Issue 1
Show Author Affiliations
Gerhard Pichler, Medical Univ. of Graz (Austria)
Karin Grossauer, Medical Univ. of Graz (Austria)
Elisabeth Peichl, Medical Univ. of Graz (Austria)
Andrea Gaster, Medical Univ. of Graz (Austria)
Andrea Berghold, Medical Univ. of Graz (Austria)
Gerold Schwantzer, Medical Univ. of Graz (Austria)
Heinz Zotter, Medical Univ. of Graz (Austria)
William Müller, Medical Univ. of Graz (Austria)
Berndt Urlesberger, Medical Univ. of Graz (Austria)

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