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Journal of Biomedical Optics

Endoscopic narrow-band imaging—quantitative assessment of airway vascularity after lung transplantation
Author(s): Sarosh Irani; Irene Thuer; Burkhardt Seifert; Rudolf Speich; Annette Boehler
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Paper Abstract

In lung transplant recipients, the submucosal vascular plexus of the airway wall potentially represents one of the key structures of graft injury. Narrow band imaging is a novel endoscope technique that allows visual enhancement of the mucosa vasculature. It was our aim to investigate the ability of narrow-band imaging in combination with computerized image analysis to quantitatively assess airway vascularity in lung transplant recipients. In consecutive lung transplant recipients, in addition to the routine procedures, optical analysis of the main carina (autologous tissue) and the upper lobe carina (allogeneic tissue) were performed. From every site, three representative pictures were chosen. A total of 63 bronchoscopies were analyzed. The intraclass correlation coefficient (measure for test–retest reliability) of the three measurements were 0.69 and 0.74 for the main carina and the upper lobe carina, respectively. A mixed linear regression revealed increased vascularity in autologous tissue of patients with cystic fibrosis (p=0.06) and decreased vascularity in allogeneic tissue with time after transplantation (p=0.09). Endoscopic narrow-band imaging (NBI) in combination with computerized image analysis allows consistent assessment of airway vascularity in vivo. In lung transplant recipients, there might be differences in airway vascularity in both autologous and allogeneic large airways.

Paper Details

Date Published: 1 January 2009
PDF: 6 pages
J. Biomed. Opt. 14(1) 014010 doi: 10.1117/1.3076189
Published in: Journal of Biomedical Optics Volume 14, Issue 1
Show Author Affiliations
Sarosh Irani, Univ. Hospital Zürich (Switzerland)
Irene Thuer, Univ. Hospital Zürich (Switzerland)
Burkhardt Seifert, Univ. of Zürich (Switzerland)
Rudolf Speich, Univ. Hospital Zürich (Switzerland)
Annette Boehler, Univ. Hospital Zürich (Switzerland)

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