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Journal of Biomedical Optics

Proof-of-principle demonstration of a Mueller matrix decomposition method for polarized light tissue characterization in vivo
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Paper Abstract

We demonstrate the first in vivo use of a Mueller matrix decomposition method for polarization-based characterization of tissue. Collagenase is injected into a region of dermal tissue in a dorsal skin window chamber in a nude mouse to alter the structure of the extracellular matrix. Mueller matrices for polarized light transmitted through the window chamber in the collagenase-treated region, as well as a distal control region, are measured. From the measured matrices, the individual constituent polarization properties of the tissue are extracted through polar matrix decomposition. Large decreases in birefringence and depolarization are seen in the collagenase-treated region due to the destruction of collagen, showing the potential for this method to monitor the organization and structural anisotropy of tissue. This study represents the first in vivo demonstration of a Mueller matrix decomposition method for polarimetric tissue characterization.

Paper Details

Date Published: 1 January 2009
PDF: 5 pages
J. Biomed. Opt. 14(1) 014029 doi: 10.1117/1.3065545
Published in: Journal of Biomedical Optics Volume 14, Issue 1
Show Author Affiliations
Michael F. Wood, Princess Margaret Hospital (Canada)
Nirmalya Ghosh, Princess Margaret Hospital (Canada)
Eduardo Hiroyuki Moriyama, Princess Margaret Hospital (Canada)
Brian C. Wilson, Princess Margaret Hospital (Canada)
I. Alex Vitkin, Univ. Health Network (Canada)

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