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Journal of Biomedical Optics

Remittance at a single wavelength of 390 nm to quantify epidermal melanin concentration
Author(s): Willem Verkruysse; Lars Othar Svaasand; Walfre Franco; J. Stuart Nelson
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Paper Abstract

Objective quantification of epidermal melanin concentration (EMC) should be useful in laser dermatology to determine the individual maximum safe radiant exposure (IMSRE). We propose a single-wavelength remittance measurement at 390 nm as an alternative optical method to determine EMC and IMSRE. Remittance spectra (360 to 740 nm), melanin index (MI) measurements and the transient radiometric temperature increase,Δ T(t), upon skin irradiation with an Alexandrite laser (755 nm, 3-ms pulse duration, 6 J/cm2) were measured on 749 skin spots (arm and calf) on 23 volunteers (skin phototypes I to IV). Due to the shallow penetration depth and independence of blood oxygen saturation (isosbestic point), remittance at 390 nm appears to provide better estimates for EMC and IMSRE than MI.

Paper Details

Date Published: 1 January 2009
PDF: 4 pages
J. Biomed. Opt. 14(1) 014005 doi: 10.1117/1.3065542
Published in: Journal of Biomedical Optics Volume 14, Issue 1
Show Author Affiliations
Willem Verkruysse, Beckman Laser Institute and Medical Clinic (United States)
Lars Othar Svaasand, Norwegian Univ. of Science and Technology (Norway)
Walfre Franco, Cutera, Inc. (United States)
J. Stuart Nelson, Beckman Laser Institute and Medical Clinic (United States)


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