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Journal of Biomedical Optics • Open Access

Improving surface-enhanced Raman scattering effect using gold-coated hierarchical polystyrene bead substrates modified with postgrowth microwave treatment
Author(s): Clement Yuen; Wei Zheng; Zhiwei Huang

Paper Abstract

We report a novel postgrowth microwave heating implementation by selectively modifying hierarchical polystyrene (PS) bead substrates coated with gold (Au) films to effectively improve the surface-enhanced Raman scattering (SERS) effect on the analytes. The SERS signal of probe molecule rhodamine 6G (Rh 6G) on the microwave-treated Au–PS substrates can be improved by 10-fold, while the detection limit of Rh 6G in concentration can be enhanced by two orders of magnitude compared to the as-growth substrates. The high-quality SERS spectrum of saliva can also be acquired using the modified substrates, demonstrating the potential for the realization of the high-performance SERS substrates for biomedical applications.

Paper Details

Date Published: 1 November 2008
PDF: 7 pages
J. Biomed. Opt. 13(6) 064040 doi: 10.1117/1.3050447
Published in: Journal of Biomedical Optics Volume 13, Issue 6
Show Author Affiliations
Clement Yuen, National Univ. of Singapore (Singapore)
Wei Zheng, National Univ. of Singapore (Singapore)
Zhiwei Huang, National Univ. of Singapore (Singapore)

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