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Journal of Biomedical Optics

Empirical model description of photon path length for differential path length spectroscopy: combined effect of scattering and absorption
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Paper Abstract

Differential path length spectroscopy (DPS) is a method of reflectance spectroscopy that utilizes a specialized fiber geometry to make the photon path length (τ) insensitive to variations in tissue optical properties over a wide range of absorption (μa) and total scattering (μs) coefficients, which are common within the ultraviolet/visible(UV/VIS) wavelength region. This study extends the description of τ to larger μa and smaller μs values, optical properties that are representative of the near-infrared region (NIR), a region where the DPS path length may be dependent on both coefficients. This study presents a novel empirical relationship between τ and the combined effect of both μa (range: 0.1–12 mm-1) and μs (range: 1.5–42 mm-1), anisotropy of 0.8, and is applicable to DPS probes containing a wide range of fiber diameters (range: 100–1000 μm). The results indicate that the simple empirical formula, including only one fitted parameter, is capable of accurately predicting over a wide range (r=0.985; range: 80–940 μm) and predictions are not biased versus μa or μs. This novel relationship is applicable to analysis of DPS measurements of tissue in both the UV/VIS and NIR wavelength regions and may provide information about the wavelength-specific tissue volume optically sampled during measurement.

Paper Details

Date Published: 1 November 2008
PDF: 8 pages
J. Biomed. Opt. 13(6) 064042 doi: 10.1117/1.3050424
Published in: Journal of Biomedical Optics Volume 13, Issue 6
Show Author Affiliations
Stephen Chad Kanick, Univ. Medisch Ctr. Rotterdam (Netherlands)
Henricus J. C. M. Sterenborg, Erasmus MC (Netherlands)
Arjen Amelink, Erasmus MC (Netherlands)

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