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Journal of Biomedical Optics

Tissue hemoglobin monitoring of progressive central hypovolemia in humans using broadband diffuse optical spectroscopy
Author(s): Jangwoen Lee; Jae Gwan Kim; Sari B. Mahon; Bruce Jason Tromberg; Kathy L. Ryan; Victor A. Convertino; Caroline A. Rickards; Kathryn Osann; Matthew Brenner
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Paper Abstract

We demonstrate noninvasive near-infrared diffuse optical spectroscopy (DOS) measurements of tissue hemoglobin contents that can track progressive reductions in central blood volume in human volunteers. Measurements of mean arterial blood pressure (MAP), heart rate (HR), stroke volume (SV), and cardiac output (Q) are obtained in ten healthy human subjects during baseline supine rest and exposure to progressive reductions of central blood volume produced by application of lower body negative pressure (LBNP). Simultaneous quantitative noninvasive measurements of tissue oxyhemoglobin (OHb), deoxyhemoglobin (RHb), total hemoglobin concentration (THb), and tissue hemoglobin oxygen saturation (StO2) are performed throughout LBNP application using broadband DOS. As progressively increasing amounts of LBNP are applied, HR increases, and MAP, SV, and Q decrease (p<0.001). OHb, StO2, and THb decrease (p<0.001) in correlation with progressive increases in LBNP, while tissue RHb remained relatively constant (p=0.378). The average fractional changes from baseline values in DOS OHb (fOHb) correlate closely with independently measured changes in SV (r2=0.95) and Q (r2=0.98) during LBNP. Quantitative noninvasive broadband DOS measurements of tissue hemoglobin parameters of peripheral perfusion are capable of detecting progressive reductions in central blood volume, and appear to be sensitive markers of early hypoperfusion associated with hemorrhage as simulated by LBNP.

Paper Details

Date Published: 1 November 2008
PDF: 10 pages
J. Biomed. Opt. 13(6) 064027 doi: 10.1117/1.3041712
Published in: Journal of Biomedical Optics Volume 13, Issue 6
Show Author Affiliations
Jangwoen Lee, Beckman Laser Institute and Medical Clinic (United States)
Jae Gwan Kim, Beckman Laser Institute and Medical Clinic (United States)
Sari B. Mahon, Beckman Laser Institute and Medical Clinic (United States)
Bruce Jason Tromberg, Univ. of California, Irvine (United States)
Kathy L. Ryan, U.S. Army Institute of Surgical Research (United States)
Victor A. Convertino, U.S. Army Institute of Surgical Research (United States)
Caroline A. Rickards, U.S. Army Institute of Surgical Research (United States)
Kathryn Osann, Univ. of California, Irvine (United States)
Matthew Brenner, Univ. of California, Irvine (United States)


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