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Journal of Biomedical Optics

Quantitative depth analysis of optic nerve head using stereo retinal fundus image pair
Author(s): Toshiaki Nakagawa; Takayoshi Suzuki; Yoshinori Hayashi; Yutaka Mizukusa; Yuji Hatanaka; Kyoko Ishida; Takeshi Hara; Hiroshi Fujita; Tetsuya Yamamoto
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Paper Abstract

Depth analysis of the optic nerve head (ONH) in the retinal fundus is important for the early detection of glaucoma. In this study, we investigate an automatic reconstruction method for the quantitative depth measurement of the ONH from a stereo retinal fundus image pair. We propose a technique to obtain the depth value from the stereo retinal fundus image pair, which mainly consists of five steps: 1. cutout of the ONH region from the stereo retinal fundus image pair, 2. registration of the stereo image pair, 3. disparity measurement, 4. noise reduction, and 5. quantitative depth calculation. Depth measurements of 12 normal eyes are performed using the stereo fundus camera and the Heidelberg Retina Tomograph (HRT), which is a confocal laser-scanning microscope. The depth values of the ONH obtained from the stereo retinal fundus image pair were in good accordance with the value obtained using HRT (r=0.80±0.15). These results indicate that our proposed method could be a useful and easy-to-handle tool for assessing the cup depth of the ONH in routine diagnosis as well as in glaucoma screening.

Paper Details

Date Published: 1 November 2008
PDF: 10 pages
J. Biomed. Opt. 13(6) 064026 doi: 10.1117/1.3041711
Published in: Journal of Biomedical Optics Volume 13, Issue 6
Show Author Affiliations
Toshiaki Nakagawa, Kowa Co., Ltd. (Japan)
Takayoshi Suzuki
Yoshinori Hayashi, TAK Co., Ltd. (Japan)
Yutaka Mizukusa, Kowa Co., Ltd. (Japan)
Yuji Hatanaka, Univ. of Shiga Prefecture (Japan)
Kyoko Ishida, Gifu Univ. School of Medicine (Japan)
Takeshi Hara, Gifu Univ. School of Medicine (Japan)
Hiroshi Fujita, Gifu Univ. School of Medicine (Japan)
Tetsuya Yamamoto

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