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Journal of Biomedical Optics • Open Access

Cost-effective diffuse reflectance spectroscopy device for quantifying tissue absorption and scattering in vivo
Author(s): Bing Yu; Justin Y. Lo; Thomas F. Kuech; Gregory M. Palmer; Janelle Elise Bender; Nirmala Ramanujam

Paper Abstract

A hybrid optical device that uses a multimode fiber coupled to a tunable light source for illumination and a 2.4-mm photodiode for detection in contact with the tissue surface is developed as a first step toward our goal of developing a cost-effective, miniature spectral imaging device to map tissue optical properties in vivo. This device coupled with an inverse Monte Carlo model of reflectance is demonstrated to accurately quantify tissue absorption and scattering in tissue-like turbid synthetic phantoms with a wide range of optical properties. The overall errors for quantifying the absorption and scattering coefficients are 6.0±5.6 and 6.1±4.7%, respectively. Compared with fiber-based detection, having the detector right at the tissue surface can significantly improve light collection efficiency, thus reducing the requirement for sophisticated detectors with high sensitivity, and this design can be easily expanded into a quantitative spectral imaging system for mapping tissue optical properties in vivo.

Paper Details

Date Published: 1 November 2008
PDF: 3 pages
J. Biomed. Opt. 13(6) 060505 doi: 10.1117/1.3041500
Published in: Journal of Biomedical Optics Volume 13, Issue 6
Show Author Affiliations
Bing Yu, Duke Univ. (United States)
Justin Y. Lo, Duke Univ. (United States)
Thomas F. Kuech, Univ. of Wisconsin, Madison (United States)
Gregory M. Palmer, Duke Univ. (United States)
Janelle Elise Bender, Duke Univ. (United States)
Nirmala Ramanujam, Duke Univ. (United States)


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