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Journal of Biomedical Optics • Open Access

Simultaneous in vivo dynamic magnetic resonance-diffuse optical tomography for small animal imaging
Author(s): Mehmet B. Unlu; Yuting Lin; Ozlem Birgul; Orhan Nalcioglu; Gultekin Gulsen

Paper Abstract

We present simultaneous measurement of enhancement kinetics of an optical and a magnetic resonance (MR) contrast agent in a small animal breast tumor model (R3230 ac) using a combined MR-diffuse optical tomographic (MR-DOT) imaging system. A mixture of a small molecular-weight MR contrast agent gadolinium-diethylene-triamine-pentaacetic acid (Gd-DTPA) and a large molecular-weight optical contrast agent indocyanine green (ICG) was administered intravenously for multimodal dynamic imaging. Coregistration of optical and MR images was accomplished using agar-water–based markers. Using T2 and dynamic T1 weighted MR images, we divided the entire tumor into two regions of interest (ROI): a viable and a nonviable region. The absorption enhancements in the ROIs were calculated. An enhancement of the ICG was observed in the viable region. On the contrary, there was a lower enhancement in the nonviable region.

Paper Details

Date Published: 1 November 2008
PDF: 3 pages
J. Biomed. Opt. 13(6) 060501 doi: 10.1117/1.3041165
Published in: Journal of Biomedical Optics Volume 13, Issue 6
Show Author Affiliations
Mehmet B. Unlu, Univ. of California, Irvine (United States)
Yuting Lin, Univ. of California, Irvine (United States)
Ozlem Birgul, Univ. of California, Irvine (United States)
Orhan Nalcioglu, Univ. of California, Irvine (United States)
Gultekin Gulsen, Univ. of California, Irvine (United States)

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