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Journal of Biomedical Optics

Diffuse optical spectroscopy measurements of healing in breast tissue after core biopsy: case study
Author(s): Vaya W. Tanamai; Cynthia Chen; Sara Siavoshi; Albert E. Cerussi; David Hsiang; John A. Butler; Bruce Jason Tromberg
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Paper Abstract

Diffuse optical spectroscopy (DOS) has been used to monitor and predict the effects of neoadjuvant (i.e., presurgical) chemotherapy in breast cancer patients in several pilot studies. Because patients with suspected breast cancers undergo biopsy prior to treatment, it is important to understand how biopsy trauma influences DOS measurements in the breast. The goal of this study was to measure the effects of a standard core breast biopsy on DOS measurements of tissue deoxyhemoglobin, hemoglobin, water, and bulk lipid concentrations. We serially monitored postbiopsy effects in the breast tissue in a single subject (31-year-old premenopausal female) with a 37×18×20 mm fibroadenoma. A baseline measurement and eight weekly postbiopsy measurements were taken with a handheld DOS imaging instrument. Our instrument used frequency domain photon migration combined with broadband steady-state spectroscopy to characterize tissues via quantitative measurements of tissue absorption and reduced scattering coefficients from 650 to 1000 nm. The concentrations of significant near-infrared (NIR) absorbers were mapped within a 50 cm2 area over the biopsied region. A 2-D image of a contrast function called the tissue optical index (TOI=deoxyhemoglobin×water/bulk lipid) was generated and revealed that a minimum of 14 days postbiopsy was required to return TOI levels in the biopsied area to their prebiopsy levels. Changes in the TOI images of the fibroadenoma also reflected the progression of the patient's menstrual cycle. DOS could therefore be useful in evaluating both wound-healing response and the effects of hormone and hormonal therapies in vivo.

Paper Details

Date Published: 1 January 2009
PDF: 9 pages
J. Biomed. Opt. 14(1) 014024 doi: 10.1117/1.3028012
Published in: Journal of Biomedical Optics Volume 14, Issue 1
Show Author Affiliations
Vaya W. Tanamai, Beckman Laser Institute and Medical Clinic (United States)
Cynthia Chen, Beckman Laser Institute and Medical Clinic (United States)
Sara Siavoshi, Beckman Laser Institute and Medical Clinic (United States)
Albert E. Cerussi, Beckman Laser Institute and Medical Clinic (United States)
David Hsiang, Univ. of California, Irvine (United States)
John A. Butler, Univ. of California, Irvine (United States)
Bruce Jason Tromberg, Univ. of California, Irvine (United States)

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