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Journal of Biomedical Optics

Retinal blood flow measurement by circumpapillary Fourier domain Doppler optical coherence tomography
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Paper Abstract

We present in vivo human total retinal blood flow measurements using Doppler Fourier domain optical coherence tomography (OCT). The scan pattern consisted of two concentric circles around the optic nerve head, transecting all retinal branch arteries and veins. The relative positions of each blood vessel in the two OCT conic cross sections were measured and used to determine the angle between the OCT beam and the vessel. The measured angle and the Doppler shift profile were used to compute blood flow in the blood vessel. The flows in the branch veins was summed to give the total retinal blood flow at one time point. Each measurement of total retinal blood flow was completed within 2 s and averaged. The total retinal venous flow was measured in one eye each of two volunteers. The results were 52.90±2.75 and 45.23±3.18 μl/min, respectively. Volumetric flow rate positively correlated with vessel diameter. This new technique may be useful in the diagnosis and treatment of optic nerve and retinal diseases that are associated with poor blood flow, such as glaucoma and diabetic retinopathy.

Paper Details

Date Published: 1 November 2008
PDF: 9 pages
J. Biomed. Opt. 13(6) 064003 doi: 10.1117/1.2998480
Published in: Journal of Biomedical Optics Volume 13, Issue 6
Show Author Affiliations
Yimin Wang, Doheny Eye Institute (United States)
Bradley A. Bower, Duke Univ. (United States)
Joseph A. Izatt, Duke Univ. (United States)
Ou Tan, Doheny Eye Institute (United States)
David Huang, Doheny Eye Institute (United States)

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