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Journal of Biomedical Optics • Open Access

Design and testing of a miniature broadband frequency domain photon migration instrument
Author(s): Keun-Sik No; Richard Y. Kwong; Pai H. Chou; Albert E. Cerussi

Paper Abstract

A board-level broadband frequency domain photon migration (mini-FDPM) instrument has been constructed to replace a conventional network-analyzer-based FDPM instrument. The mini-FDPM instrument with four wavelengths (681, 783, 823, and 850 nm), matches conventional FDPM instrument in performance (-88 dBm noise level, 100 dB dynamic range) and bandwidth (1 GHz), and recovers the same optical properties within about 6% in absorption and 4% in reduced scattering for liquid phantoms covering a wide range of relevant optical properties. Compared to the conventional FDPM instrument, the mini-FDPM instrument is more than 5× faster (~200 ms per 401 modulation frequencies) and several orders of magnitude less in size and cost. Standard fiber-optic-based probes can be used with the mini-FDPM instrument, which increases applications in a number of clinically relevant measurement scenarios. By drastically reducing size and cost, FDPM miniaturization lowers barriers to access and will help promote FDPM in clinical research problems. The mini-FDPM instrument forms the core of a modular broadband diffuse optical spectroscopy instrument that can be used for a variety of clinical problems in imaging and functional monitoring (i.e., breast/skin cancer, brain activation, and exercise physiology).

Paper Details

Date Published: 1 September 2008
PDF: 3 pages
J. Biomed. Opt. 13(5) 050509 doi: 10.1117/1.2998473
Published in: Journal of Biomedical Optics Volume 13, Issue 5
Show Author Affiliations
Keun-Sik No, Beckman Laser Institute and Medical Clinic (United States)
Richard Y. Kwong, Beckman Laser Institute and Medical Clinic (United States)
Pai H. Chou, Univ. of California, Irvine (United States)
Albert E. Cerussi, Beckman Laser Institute and Medical Clinic (United States)

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