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Journal of Biomedical Optics

Combined ultrasound and photoacoustic imaging to detect and stage deep vein thrombosis: phantom and ex vivo studies
Author(s): Andrei B. Karpiouk; Salavat R. Aglyamov; Srivalleesha Mallidi; Jignesh Shah; William G. Scott; Jonathan M. Rubin; Stanislav Y. Emelianov
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Paper Abstract

Treatment of deep venous thrombosis (DVT)—a primary cause of potentially fatal pulmonary embolism (PE)—depends on the age of the thrombus. The existing clinical imaging methods are capable of visualizing a thrombus but cannot determine the age of the blood clot. Therefore, there is a need for an imaging technique to reliably diagnose and adequately stage DVT. To stage DVT (i.e., to determine the age of the thrombus, and therefore, to differentiate acute from chronic DVT), we explored photoacoustic imaging, a technique capable of noninvasive measurements of the optical absorption in tissue. Indeed, optical absorption of the blood clot changes with age, since maturation of DVT is associated with significant cellular and molecular reorganization. The ultrasound and photoacoustic imaging studies were performed using DVT-mimicking phantoms and phantoms with embedded acute and chronic thrombi obtained from an animal model of DVT. The location and structure of the clots were visualized using ultrasound imaging, while the composition, and therefore age, of thrombi were related to the magnitude and spatiotemporal characteristics of the photoacoustic signal. Overall, the results of our study suggest that combined ultrasound and photoacoustic imaging of thrombi may be capable of simultaneous detection and staging of DVT.

Paper Details

Date Published: 1 September 2008
PDF: 8 pages
J. Biomed. Opt. 13(5) 054061 doi: 10.1117/1.2992175
Published in: Journal of Biomedical Optics Volume 13, Issue 5
Show Author Affiliations
Andrei B. Karpiouk, The Univ. of Texas at Austin (United States)
Salavat R. Aglyamov, The Univ. of Texas at Austin (United States)
Srivalleesha Mallidi, The Univ. of Texas at Austin (United States)
Jignesh Shah, The Univ. of Texas at Austin (United States)
William G. Scott, Univ. of California, Santa Cruz (United States)
Jonathan M. Rubin, Univ. of Michigan (United States)
Stanislav Y. Emelianov, The Univ. of Texas at Austin (United States)

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