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Journal of Biomedical Optics

Detection of macrophages in atherosclerotic tissue using magnetic nanoparticles and differential phase optical coherence tomography
Author(s): Junghwan Oh; Marc D. Feldman; H. Golombek; Jihoon Kim; Pramod Sanghi; Dat Do; J. Jacob Mancuso; Nathaniel Joseph Kemp; Mehmet Cilingiroglu; Thomas E. Milner
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Paper Abstract

We demonstrate the detection of iron oxide nanoparticles taken up by macrophages in atherosclerotic plaque with differential phase optical coherence tomography (DP-OCT). Magneto mechanical detection of nanoparticles is demonstrated in hyperlipidemic Watanabe and balloon-injured fat-fed New Zealand white rabbits injected with monocrystalline iron oxide nanoparticles (MIONs) of <40 nm diam. MIONs taken up by macrophages was excited by an oscillating magnetic flux density and resulting nanometer tissue surface displacement was detected by DP-OCT. Frequency response of tissue surface displacement in response to an externally applied magnetic flux density was twice the stimulus frequency as expected from the equations of motion for the nanoparticle cluster.

Paper Details

Date Published: 1 September 2008
PDF: 8 pages
J. Biomed. Opt. 13(5) 054006 doi: 10.1117/1.2985762
Published in: Journal of Biomedical Optics Volume 13, Issue 5
Show Author Affiliations
Junghwan Oh, The Univ. of Texas M.D. Anderson Cancer Ctr. (United States)
Marc D. Feldman, The Univ. of Texas Health Science Ctr. at San Antonio (United States)
H. Golombek, Tel Aviv Univ. (Israel)
Jihoon Kim, The Univ. of Texas Health Science Ctr. at San Antonio (United States)
Pramod Sanghi, The Univ. of Texas Health Science Ctr. at San Antonio (United States)
Dat Do, The Univ. of Texas Health Science Ctr. at San Antonio (United States)
J. Jacob Mancuso, The Univ. of Texas Health Science Ctr. at San Antonio (United States)
Nathaniel Joseph Kemp, Volcano Corp. (United States)
Mehmet Cilingiroglu, The Univ. of Texas Health Science Ctr. at San Antonio (United States)
Thomas E. Milner, The Univ. of Texas at Austin (United States)


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