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Journal of Biomedical Optics

Analysis of hollow-core photonic bandgap fibers for evanescent wave biosensing
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Paper Abstract

Hollow-core photonic bandgap fiber (HC-PBGF)–based evanescent wave biosensors are demonstrated and analyzed theoretically and experimentally. With 95% of the guided light power residing in the samples, the measured absorbance for a 30-cm-long fiber filled with a 0.2 μM Alexa Fluor 700–labeled DNA Oligo solution is 1.06. This is in good agreement with the theoretical prediction, which is evaluated by using the refractive index scaling law. The HC-PBGFs thus offer both efficiency and simplicity for the detection of biomolecules in ultra-small sample volumes.

Paper Details

Date Published: 1 September 2008
PDF: 6 pages
J. Biomed. Opt. 13(5) 054048 doi: 10.1117/1.2983676
Published in: Journal of Biomedical Optics Volume 13, Issue 5
Show Author Affiliations
Jian Sun, Nanyang Technological Univ. (Singapore)
Chi-Chiu Chan, Nanyang Technological Univ. (Singapore)
Yifan Zhang, Nanyang Technological Univ. (Singapore)
Ping Shum, Nanyang Technological Univ. (Singapore)

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