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Journal of Biomedical Optics

Manipulation of mammalian cells using a single-fiber optical microbeam
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Paper Abstract

The short working distance of microscope objectives has severely restricted the application of optical micromanipulation techniques at larger depths. We show the first use of fiber-optic tweezers toward controlled guidance of neuronal growth cones and stretching of neurons. Further, by mode locking, the fiber-optic tweezers beam was converted to fiber-optic scissors, enabling dissection of neuronal processes and thus allowing study of the subsequent response of neurons to localized injury. At high average powers, lysis of a three-dimensionally trapped cell was accomplished.

Paper Details

Date Published: 1 September 2008
PDF: 7 pages
J. Biomed. Opt. 13(5) 054049 doi: 10.1117/1.2983663
Published in: Journal of Biomedical Optics Volume 13, Issue 5
Show Author Affiliations
Samarendra Kumar Mohanty, Raja Ramanna Ctr. for Advanced Technology (India)
Khyati Mohanty, Univ. of California, Irvine (United States)
Michael W. Berns, Univ. of California, Irvine (United States)

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