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Journal of Biomedical Optics

Stochastic decomposition method for modeling the scattered signal reflected of mucosal tissues
Author(s): Fernand S. Cohen; Ezgi Taslidere; Dilip S. Hari; Sreekant Murthy
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Paper Abstract

The aim of this work is to draw the attention of the biophotonics community to a stochastic decomposition method (SDM) to potentially model 2-D scans of light scattering data from epithelium mucosa tissue. The emphasis in this work is on the proposed model and its theoretical pinning and foundation. Unlike previous works that analyze scattering signal at one spot as a function of wavelength or angle, our method statistically analyzes 2-D scans of light scattering data over an area. This allows for the extraction of texture parameters that correlate with changes in tissue morphology, and physical characteristics such as changes in absorption and scattering characteristics secondary to disease, information that could not be revealed otherwise. The method is tested on simulations, phantom data, and on a limited preliminary in-vitro animal experiment to track mucosal tissue inflammation over time, using the area Az under receiver operating characteristics (ROC) curve as a performance measure. Combination of all the features results in an Az value up to 1 for the simulated data, and Az>0.927 for the phantom data. For the tissue data, the best performances for differentiation between pairs of various levels of inflammation are 0.859, 0.983, and 0.999.

Paper Details

Date Published: 1 September 2008
PDF: 14 pages
J. Biomed. Opt. 13(5) 054039 doi: 10.1117/1.2982527
Published in: Journal of Biomedical Optics Volume 13, Issue 5
Show Author Affiliations
Fernand S. Cohen, Drexel Univ. (United States)
Ezgi Taslidere, Drexel Univ. (United States)
Dilip S. Hari, Drexel Univ. (United States)
Sreekant Murthy, Drexel Univ. College of Medicine (United States)

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