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Journal of Biomedical Optics

Confidence intervals on fit parameters derived from optical reflectance spectroscopy measurements
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Paper Abstract

We validate a simple method for determining the confidence intervals on fitted parameters derived from modeling optical reflectance spectroscopy measurements using synthetic datasets. The method estimates the parameter confidence intervals as the square roots of the diagonal elements of the covariance matrix, obtained by multiplying the inverse of the second derivative matrix of Χ2 with respect to its free parameters by Χ2/v, with v the number of degrees of freedom. We show that this method yields correct confidence intervals as long as the model used to describe the data is correct. Imperfections in the fitting model introduces a bias in the fitted parameters that greatly exceeds the estimated confidence intervals. We investigate the use of various methods to identify and subsequently minimize the bias in the fitted parameters associated with incorrect modeling.

Paper Details

Date Published: 1 September 2008
PDF: 14 pages
J. Biomed. Opt. 13(5) 054044 doi: 10.1117/1.2982523
Published in: Journal of Biomedical Optics Volume 13, Issue 5
Show Author Affiliations
Arjen Amelink, Erasmus Univ. Medical Ctr. (Netherlands)
Dominic J. Robinson, Erasmus Univ. Medical Ctr. (Netherlands)
Henricus J. C. M. Sterenborg, Erasmus Univ. Medical Ctr. (Netherlands)

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