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Journal of Biomedical Optics • Open Access

In-vivo singlet oxygen dosimetry of clinical 5-aminolevulinic acid photodynamic therapy
Author(s): Hans Laubach; Sung K. Chang; Seonkyung Lee; Imran Rizvi; David Zurakowski; Steven J. Davis; Charles R. Taylor; Tayyaba Hasan

Paper Abstract

Photodynamic therapy (PDT) is a viable treatment option for a wide range of applications, including oncology, dermatology, and ophthalmology. Singlet oxygen is believed to play a key role in the efficacy of PDT, and on-line monitoring of singlet oxygen during PDT could provide a methodology to establish and customize the treatment dose clinically. This work is the first report of monitoring singlet oxygen luminescence in vivo in human subjects during PDT, demonstrating the correlation of singlet oxygen levels during PDT with the post-PDT photobiological response.

Paper Details

Date Published: 1 September 2008
PDF: 3 pages
J. Biomed. Opt. 13(5) 050504 doi: 10.1117/1.2981813
Published in: Journal of Biomedical Optics Volume 13, Issue 5
Show Author Affiliations
Hans Laubach, Wellman Ctr. for Photomedicine (United States)
Sung K. Chang, Massachusetts General Hospital (United States)
Seonkyung Lee, Physical Sciences Inc. (United States)
Imran Rizvi, Wellman Ctr. for Photomedicine (United States)
David Zurakowski, Children's Hospital Boston (United States)
Steven J. Davis, Physical Sciences Inc. (United States)
Charles R. Taylor, Massachusetts General Hospital (United States)
Tayyaba Hasan, Massachusetts General Hospital (United States)

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