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Journal of Biomedical Optics • Open Access

Lookup table–based inverse model for determining optical properties of turbid media
Author(s): Narasimhan Rajaram; Tri Nguyen; James W. Tunnell

Paper Abstract

We present a lookup table (LUT)–based inverse model for determining the optical properties of turbid media from steady-state diffuse reflectance spectra that is valid for fiber-based probe geometries with close source-detector separations and tissue with low albedo. The lookup table is based solely on experimental measurements of calibration standards. We used tissue-simulating phantoms to validate the accuracy of the LUT inverse model. Our results show excellent agreement between the expected and extracted values of the optical parameters. In addition, the LUT represents a significant improvement in accuracy at short source-detector separations (300 μm) and low albedo (~0.35). We also present in vivo data from clinically normal and malignant nonmelanoma skin cancers fit to the LUT-based model.

Paper Details

Date Published: 1 September 2008
PDF: 3 pages
J. Biomed. Opt. 13(5) 050501 doi: 10.1117/1.2981797
Published in: Journal of Biomedical Optics Volume 13, Issue 5
Show Author Affiliations
Narasimhan Rajaram, The Univ. of Texas at Austin (United States)
Tri Nguyen, The Univ. of Texas M.D. Anderson Cancer Ctr. (United States)
James W. Tunnell, The Univ. of Texas at Austin (United States)

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