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Journal of Biomedical Optics

High-resolution imaging diagnosis and staging of bladder cancer: comparison between optical coherence tomography and high-frequency ultrasound
Author(s): Zhijia Yuan; Zhenguo Wang; Rubin Pan; Jingxuan Liu; Harris Cohen; Yingtian Pan
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Paper Abstract

A comparative study between 1.3-μm optical coherence tomography (OCT) and 40-MHz high-frequency ultrasound (HFUS) is presented to enhance imaging of bladder cancers ex vivo. A standard rat bladder cancer model in which transitional cell carcinoma (TCC) was induced by intravesical instillation of AY-27 cells was followed independently with both OCT and HFUS, and the image identifications were compared to histological confirmations. Results indicate that both OCT and HFUS were able to delineate the morphology of rat bladder [e.g., the urothelium (low backscattering/echo) and the underlying lamina propria and muscularis (high backscattering/echo]. OCT differentiated inflammatory lesions (e.g., edema, infiltrates and vasodilatation in lamina propria, hyperplasia) and TCC based on characterization of urothelial thickening and enhanced backscattering or heterogeneity (e.g., papillary features), which HFUS failed due to insufficient image resolution and contrast. On the other hand, HFUS was able to stage large T2 tumors that OCT failed due to limited imaging depth. The results suggest that multimodality cystoscopy combining OCT and HFUS may have the potential to enhance the diagnosis and staging of bladder cancers and to guide tumor resection, in which both high resolution (~10 μm) and enhanced penetration (>3mm) are desirable.

Paper Details

Date Published: 1 September 2008
PDF: 10 pages
J. Biomed. Opt. 13(5) 054007 doi: 10.1117/1.2978059
Published in: Journal of Biomedical Optics Volume 13, Issue 5
Show Author Affiliations
Zhijia Yuan, Stony Brook Univ. (United States)
Zhenguo Wang, Stony Brook Univ. (United States)
Rubin Pan, Stony Brook Univ. (United States)
Jingxuan Liu, Stony Brook Univ. (United States)
Harris Cohen, Stony Brook Univ. (United States)
Yingtian Pan, Stony Brook Univ. (United States)

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