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Journal of Biomedical Optics

Direct estimation of evoked hemoglobin changes by multimodality fusion imaging
Author(s): Theodore J. Huppert; Solomon G. Diamond; David A. Boas
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Paper Abstract

In the last two decades, both diffuse optical tomography (DOT) and blood oxygen level dependent (BOLD)-based functional magnetic resonance imaging (fMRI) methods have been developed as noninvasive tools for imaging evoked cerebral hemodynamic changes in studies of brain activity. Although these two technologies measure functional contrast from similar physiological sources, i.e., changes in hemoglobin levels, these two modalities are based on distinct physical and biophysical principles leading to both limitations and strengths to each method. In this work, we describe a unified linear model to combine the complimentary spatial, temporal, and spectroscopic resolutions of concurrently measured optical tomography and fMRI signals. Using numerical simulations, we demonstrate that concurrent optical and BOLD measurements can be used to create cross-calibrated estimates of absolute micromolar deoxyhemoglobin changes. We apply this new analysis tool to experimental data acquired simultaneously with both DOT and BOLD imaging during a motor task, demonstrate the ability to more robustly estimate hemoglobin changes in comparison to DOT alone, and show how this approach can provide cross-calibrated estimates of hemoglobin changes. Using this multimodal method, we estimate the calibration of the 3tesla BOLD signal to be −0.55%±0.40% signal change per micromolar change of deoxyhemoglobin.

Paper Details

PDF: 15 pages
J. Biomed. Opt. 13(5) 054031 doi: 10.1117/1.2976432
Published in: Journal of Biomedical Optics Volume 13, Issue 5, September 2008
Show Author Affiliations
Theodore J. Huppert, Massachusetts General Hospital (United States)
UPMC Presbyterian (United States)
Solomon G. Diamond, Massachusetts General Hospital (United States)
Dartmouth College (United States)
David A. Boas, Massachusetts General Hospital (United States)
Massachusetts Institute of Technology (United States)
Athinoula A. Martinos Ctr. for Biomedical Imaging (United States)


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