Share Email Print

Journal of Biomedical Optics • Open Access

Label-free in vivo optical imaging of microvasculature and oxygenation level
Author(s): Dan Fu; Thomas E. Matthews; Tong Ye; Ivan Piletic; Warren S. Warren

Paper Abstract

The ability to perform high-resolution imaging of microvasculature and its oxygenation is very important in studying early tumor development. Toward this goal, we improved upon our excited state absorption (ESA)–based imaging technique to allow us to not only image hemoglobin directly but also differentiate between oxy- and deoxyhemoglobin in tissue. We demonstrate the separation of arterioles from venules in a live nude mouse ear using our imaging technique.

Paper Details

Date Published: 1 July 2008
PDF: 3 pages
J. Biomed. Opt. 13(4) 040503 doi: 10.1117/1.2968260
Published in: Journal of Biomedical Optics Volume 13, Issue 4
Show Author Affiliations
Dan Fu, Duke Univ. (United States)
Thomas E. Matthews, Duke Univ. (United States)
Tong Ye, The Univ. of Alabama at Birmingham (United States)
Ivan Piletic, Stanford Univ. (United States)
Warren S. Warren, Duke Univ. (United States)

© SPIE. Terms of Use
Back to Top