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Journal of Biomedical Optics

Optimal probe design for breast imaging using near-infrared diffused light
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Paper Abstract

Shallow lesions less than 1.5-cm deep are frequently seen in breast patients when they are scanned in reflection geometry. Two boundary conditions are compared for imaging shallow lesions, and a new probe design is introduced. A partial reflection boundary condition is suitable for imaging shallow lesions less than 1.0-cm deep; whereas an absorption boundary condition is desirable for imaging lesions more than 1.5-cm deep. Our new probe design incorporates either a partial reflection boundary or an absorption boundary based on a priori knowledge of lesion depth provided by coregistered real-time ultrasound images. An angled source is introduced to further improve the illumination of the region between 1.0- to 1.5-cm depths. Simulation, phantom, and freshly excised mouse tumor experiments demonstrate that targets located at different depths can be uniformly reconstructed. A clinical example is given to demonstrate the utility of this new approach for optimally probing lesions located at different depths.

Paper Details

Date Published: 1 July 2008
PDF: 10 pages
J. Biomed. Opt. 13(4) 044002 doi: 10.1117/1.2966703
Published in: Journal of Biomedical Optics Volume 13, Issue 4
Show Author Affiliations
Chen Xu, Univ. of Connecticut (United States)
Baohong Yuan, The Catholic Univ. of America (United States)
Quing Zhu, Univ. of Connecticut (United States)

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